Search on: HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES 
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Descriptor English:   Hypoxia-Inducible Factor-Proline Dioxygenases 
Descriptor Spanish:   Prolina Dioxigenasas del Factor Inducible por Hipoxia 
Descriptor Portuguese:   Prolina Dioxigenases do Fator Induzível por Hipóxia 
Tree Number:   D08.811.682.690.416.617.500
D08.811.682.690.708.694.500
Definition English:   Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular adaptive responses to HYPOXIA. 
History Note English:   2014 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   55296 
Unique Identifier:   D064799 

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